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Gallbladder disease (GBD) is a common health concern that affects millions across the world. Your access to this site has been limited by the site owner If you think you have been blocked in error, contact the owner of this site for assistance. If you are a WordPress user with Cannabidiol, also known as CBD, has a number of known benefits for brain health, immunity, pain management, and gut health including for gallbladders.

CBD for Gallbladder: What does the Science Say?

Gallbladder disease (GBD) is a common health concern that affects millions across the world.

According to the NHANES III, “a total of 20.5 million persons in the United States, 6.3 million men and 14.2 million women, aged 20–74 years, were estimated to have GBD”.

CBD addresses the symptoms of gallbladder problems that cause a lot of discomfort in the patients. But does it actually work? Is it even safe to use?

To understand all of this, we have compiled various studies and researches about CBD and its benefits for gallbladder problems. Read on!

What are Gallbladder Problems?

The gallbladder is a pear-shaped organ present under the liver on the upper right section of the abdomen. It stores bile, a digestive fluid produced by the liver. This fluid is released into the small intestine for proper digestion of fats.

Gallstones or cholelithiasis is the most common gallbladder disease. They are hardened deposits of the bile in the gallbladder.

The size may vary from that of sand grain to a golf ball. The patient can develop one-to-many gallstones at the same time.

Gallstones mostly affect women above the age of 40. According to the Mayo Clinic , it may happen due to the following:

High cholesterol in the bile: When the liver produces more cholesterol than the bile can dissolve, the excess cholesterol forms crystals and then gallstones in the gallbladder.

High bilirubin in the bile: Bilirubin is a chemical that breaks down the RBCs in the body. The body produces excess bilirubin in conditions like liver cirrhosis, biliary tract infections. This leads to gallstone formation.

Inability to empty the bladder correctly: When your bladder doesn’t get empty correctly, the bile gets concentrated and eventually forms gallstones.

Types of Gallstones

Cholesterol gallstones: These stones are usually yellow in color. This is a more common type of gallstones that are formed due to undissolved cholesterol.

Pigment gallstones : Due to the excess bilirubin content, these gallstones are brown and black in color.

Other types of gallbladder diseases are:

Cholecystitis, Common bile duct infection, common bile duct stones (choledocholithiasis), gallbladder disease without stones, perforated gallbladder, abscess of the gallbladder, and many more.

Symptoms of Gallbladder Disease

Here are a few common symptoms one may experience:

  • Pain
  • Inflammation
  • Nausea and vomiting
  • Fever
  • Chronic diarrhea

Treatment for gallbladder Problems

Depending upon the type of problem, the treatments may include:

  • over-the-counter pain medications, like ibuprofen
  • prescription pain medications, like hydrocodone and morphine
  • surgery to remove gallstones
  • Cholecystectomy: s urgery to remove the whole gallbladder
  • lithotripsy, a medical procedure where shock waves are used to break stones in the gallbladder and other organs

Can CBD help with Gallbladder Pain and Inflammation?

Cannabidiol is a non-psychoactive component of the Cannabis Sativa plant. Extracted from the hemp plant, CBD has several therapeutic and health benefits. Pure CBD products don’t contain tetrahydrocannabinol ( THC) intoxicating compound

CBD provides relief in gallbladder problems. It also helps in alleviating gastrointestinal symptoms.

People are resorting to cannabinoids as a natural alternative to usual pain medications. This is because drugs like NSAIDs and prescription medicines can have long-term adverse side effects.

CBD is arising as a potential treatment for gallbladder problems due to its interaction with the endocannabinoid system (ECS).

The ECS is responsible for regulation of pain, sleep, memory, mood, immune response, and other functions in the body.

CBD works to maintain homeostasis (balance) in the body to inhibit the pain sensation, a major symptom of gallbladder diseases.

A 2013 review talked about the role of the endocannabinoid system and the phytocannabinoids in chronic pain management.

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How does CBD help with Gallbladder problems?

According to a 2017 study, “CBD is mostly devoid of adverse psychoactive effects and possesses anticonvulsant, analgesic, anti-anxiety, antiemetic, immune-modulating, anti-inflammatory, neuroprotectant, and anti-tumorigenic properties”.

As mentioned above, CBD not only aids in gallbladder problems but also takes care of the gastrointestinal issues. It also supports gut health and relieves digestive issues.

It works to protect the intestinal cells and gallbladder from chemical or inflammatory damage and inhibits the development of harmful diseases.

Based on the studies and researches available, here’s how CBD can help the patients with Gallbladder and GI issues:

Reduces Inflammation and Pain

Inflammation is the body’s natural response to infection or injury. Chronic inflammation is a common symptom in people suffering from the gallbladder and gastrointestinal issues.

CBD has anti-inflammatory properties, and it works through various receptors, fatty acids, hormones, and cell-signaling proteins to reduce the discomfort in the patient.

Pain is another major symptom of gallbladder disease. The pain can be dull, achy, sharp, or sudden depending on the cause. It affects the abdomen to the lower back.

CBD has analgesic (pain-relieving) properties that can decrease discomfort in the patients

A 2004 study revealed that CBD interacts with the vanilloid TRPV1 receptor to produce its anti-hyperalgesic effect . It was used to treat acute inflammation in a rat model.

CBD has antinociceptive effects t hrough which it can prevent the detection of painful signals by the sensory neurons. That’s why its effects last longer than the usual painkillers .

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Heals Leaky Gut

Leaky gut or intestinal permeability is a digestive condition that affects the lining of the intestines. Here the bacteria and toxins leak from the intestinal walls into the bloodstream.

The common symptoms of leaky gut are inflammation, abdominal pain, gas, bloating, etc. It can further lead to gallstones and gastrointestinal diseases.

CBD may help in relieving this condition. A 2017 study concluded that CBD can “ restore the intestinal barrier integrity, through the involvement of the CB1 receptor”.

A 2012 study showed that “phytocannabinoids have therapeutic potential for reversing the disordered intestinal permeability associated with inflammation”.

In another 2019 study , it was revealed that CBD when taken with palmitoylethanolamide (PEA) can reduce intestinal hyper-permeability (leaky gut) induced by inflammation. This is also beneficial for people with Irritable bowel syndrome.

Improves Metabolism

The endocannabinoid system also regulates the metabolic function in the body. It is made up of metabolic enzymes that help in energy storage, transportation of nutrients, and insulin sensitivity.

A 2012 study i nvestigated the association between metabolic syndrome and the development of gallstone disease (GSD). It concluded that more the components of metabolic syndrome are there in the body, higher is the prevalence of GSD.

The use of CBD has shown significant development in treating metabolic disorders like diabetes . However, we require specific studies to prove their use for gallstones.

CBD turns the white fat cells into brown to prevent the risk of obesity. This further leads to increased lipolysis, thermogenesis, and reduction of lipogenesis. It, therefore, improves the user’s metabolic health.

Promotes Brain Health

The discomfort in your gut also affects brain function. A 2019 study talks about this gut-brain connection.

The inflammation in the gut usually causes brain fog, lack of concentration, and even anxiety. It also leads to inflammation in the brain which could develop into neurodegenerative disease.

A 2018 review revealed that CBD can attenuate acute autonomic responses induced by stress by activating the 5HT1A (serotonin) receptors.

Also, it concluded that CBD can show neuroprotective effects by activating the adenosine receptors. It can enhance the signaling of adenosine to mediate immunosuppressive and anti-inflammatory effects in the body.

Pros and Cons of using CBD to Treat Your Gallbladder Problems

Before using CBD for your gallbladder condition, let’s understand its pros and cons:

Pros

  • CBD helps alleviate pain and inflammation in the gallbladder.
  • Helps heal leaky gut and promotes overall health by taking care of metabolism and the brain.
  • According to the World Health Organization (WHO) , “CBD is

generally well-tolerated with a good safety profile”.

  • The patient cannot develop tolerance or get addicted to CBD. It delivers therapeutic benefits without making them ‘high’.
  • Has relatively milder side effects than medication drugs.

Cons

  • There are limited studies related to CBD’s efficacy for gallbladder problems.
  • There’s no standard CBD dosage prescribed for its usage for gallbladder.
  • The Food and Drug Administration (FDA) doesn’t regulate CBD except in the case of epilepsy .
  • Due to the lack of regulation and standardization, low quality, mislabelled CBD products are being sold in the market that can be harmful.

CBD and Alternative Treatments for Gallbladder Problems

Many patients go for complementary and alternative therapies (CAM) to relieve gallbladder pain. They can also prevent the further development of gallbladder diseases. This should be done in supervision of a healthcare practitioner. Here’s what all it includes:

Maintain a healthy weight: Being obese puts you at risk for various gallbladder problems. It is important to maintain a healthy weight, reducing your calorie intake, and indulging regular exercise.

CBD also helps in improving your metabolism and reduces the risk of gallbladder diseases related to metabolic syndrome.

Dietary changes: To lower the plasma insulin levels, it is important to make significant changes in your diet. Eliminate fatty foods and refined carbohydrates from your diet.

Try having unrefined carbs like whole grains, legumes, and starchy vegetables.

Like CBD, these foods will help in reducing inflammation as they get digested slowly and ensure a steady dosage of sugar in your body.

Herbal medicine: You can also rely on turmeric, bupleurum, Oregon grape, and coin grass to reduce the painful inflammation caused by the gallbladder diseases. It may also relieve liver congestion.

CBD is also a herbal compound that comes from plants and treats the health ailments naturally. You can easily add it to your wellness routine.

How to take CBD for Gallbladder?

CBD is available in many forms in the market for you to choose from. Take a look:

CBD Oil

The most common way to take Cannabidiol is in the form of oil tincture. As oils are molecular carriers, they hold more cannabinoids than other CBD products. They easily get absorbed into the bloodstream to show desired effects.

How to use : The best way to take CBD oil is sublingually. You need to put it under the tongue and let it sit for 90 seconds and then swallow it. The effects will appear in 15 to 45 minutes.

You can also have CBD oil in the form of capsules, edibles like gummies, baked goods.

CBD Topicals

Another way to use CBD is through CBD topicals. This includes ointments, lotions, and salves. These topicals get absorbed in the skin to provide relief in the affected areas.

How to use: Apply the cream generously on the upper abdomen or back area at the site of the pain. You can reapply it after 30-60 minutes until the pain reduces.

Pro tip: Always check the ingredients of the topical to check if you are not allergic to any of them.

CBD Dosage for Gallbladder Problems

Unfortunately, there is no recommended dosage of CBD for gallbladder diseases. It may depend on your weight, metabolism, cause of the pain, and its severity.

Finding the right dosage is a process of trials and experimentation.

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You can either follow the instructions on the package or start with the lowest dosage.

Increase the dosage as required. Once you get the desired effects, stick to that dosage.

For further assistance, consult your doctor.

Side Effects of CBD

Although you cannot develop a tolerance or addiction towards CBD, it is important you do not overindulge in it.

It may cause some mild side-effects, like:

  • Dry mouth
  • Nausea
  • Tiredness
  • Headache

If the side effects become too severe, we advise you to discontinue the use.

Conclusion: Should you try?

Although there is a long way to go for CBD as a potential gallbladder treatment, the present researches spark a promising light of hope. It may become a natural alternative to the drugs currently being used.

As CBD can be procured without any proper prescription, the risk of its side effects also increases. It may even interact with your over the counter (OTC) medications.

Therefore, we recommend you to consult your healthcare provider before taking CBD for any gallbladder problem. They shall let you know if it is safe for you to use given your medical state.

We hope we helped you understand the efficacy of CBD for gallbladder problems. Stay healthy, stay fit!

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CBD Benefits

Cannabis – a word that stirs a lot of discussion and debate. But when we come to think of it, it’s just an herb, a plant that has been used for medicinal, religious, and trading purposes for decades. However, despite its historical merits, it is still considered controversial. Due to its psychotropic effects, it was declared illegal in the 17th century US.

Fortunately, a series of major discoveries about the plant and its connection to the human body prevailed. In 1964, scientists from Israel were able to identify and synthesize the cannabinoid tetrahydrocannabinol (THC). Soon after, other cannabinoids were identified, including cannabidiol (CBD). Another milestone achieved was in 1988 when scientists determined that the mammalian brain has receptor sites that respond pharmacologically to cannabinoids. These cannabinoid receptors comprise the endocannabinoid system (ECS), a network of specialized protein molecules embedded in cell membranes that affect various homeostatic functions.

Since those discoveries were made, more and more studies emphasizing the therapeutic effects of cannabis have been conducted. These boosted the popularity of CBD oil, a component of cannabis that doesn’t have the same hallucinogenic and mind-altering effect as the whole plant. Today, following some states’ legalization, CBD is slowly making its way to the mainstream pharmacological world.

How does CBD work?

CBD is one of the 85 known cannabinoids in cannabis. It is often confused and mistaken for THC, cannabis’ intoxicating component that gives the feeling of being “high.” CBD, however, does not trigger the same effect. Instead, it has been proven to have numerous healing properties, and it can counteract some negative effects of THC. In various studies, CBD has been identified as anti-inflammatory, anticonvulsant, anti-oxidant, anti-emetic, anti-tumorigenic, analgesic,
anxiolytic and antipsychotic. These properties make it a potential medicine for the treatment of numerous diseases.

CBD acts through the endocannabinoid system of the body. It also causes direct or indirect activation of various receptor-independent channels and different non-cannabinoid receptors and ion channels. These networks give CBD the ability to induce various effects through multiple molecular pathways. CBD’s interaction with these channels has been the subject of extensive research in the field of pharmacology. One of CBD’s most documented attributes is its anti-inflammatory property.

CBD for Inflammation

As we have emphasized time and again, inflammation is our body’s natural defense response to pathogens and injury. To a considerable extent, we need it. However, ongoing systemic inflammation is implicated in the development of many chronic and debilitating diseases. Patients with gallbladder and gastrointestinal issues should be particularly worried about chronic inflammation.

There are a lot of synthetic and natural anti-inflammatories available in the market today, but none of them work like CBD.

CBD counteracts inflammation via different pathways. It interacts with various receptors, hormones, fatty acids, and cell-signaling proteins to produce an anti-inflammatory effect. These may sound technical, but it is good to know that CBD has more ways than one to reduce or manage inflammation in the body.

5 CBD Health Benefits for Gallbladder and GI Patients

CBD can help patients suffering from the gallbladder and gastrointestinal diseases by:

1. addressing gastrointestinal symptoms and healing leaky gut.

2. reducing pain.

3. supporting metabolism.

4. supporting brain health.

5. supporting the immune system

CBD for Gut Health

Leaky gut is a common gastrointestinal problem characterized by various symptoms, including inflammation, gas, bloating, abdominal pain, and fatigue. It is caused by the disruption of the gut’s tight junctions to prevent the passage of toxic waste, undigested food, and harmful microorganisms into the bloodstream. Leaky gut may contribute to gallstones and the development of other GI diseases.

Although there is still no medicine that can instantly heal a leaky gut, there are many things we can do to help our body heal itself. We usually recommend the removal of any possible aggravations such as stress and avoidance of common food allergens. Once that is done, several supplements can be taken to allow the lining to heal.

One of the natural agents that can promote this action is CBD.

CBD decreases intestinal permeability by boosting the expression of a protein called claudin, which is responsible for cell-to-cell adhesion. CBD’s anti-inflammatory property also reduces intestinal damage mediated by a receptor pathway called PPARgamma. These mechanisms are beneficial not just for leaky gut patients but for those with inflammatory bowel diseases.

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Patients with sepsis, Crohn’s disease, IBD, and BAD or bile acid diarrhea may also benefit from CBD’s ability to slow down gastric emptying and intestinal transit. Those with hyperacidity or GERD will also be glad that CBD can inhibit gastric acid secretion.

CBD for Pain Management

Cannabis is therapeutically famous as a pain-killer. That is why some patients with chronic pain or under palliative care are fighting to have access to it. Luckily, with the discovery of isolating CBD oil, many individuals can now use it legally and without the euphoric effect of THC in cannabis.

Upon ingestion or administration, CBD can bind to vanilloid receptors in the body, which mediate pain perception, inflammation, and body temperature. This is one reason why some studies refer to CBD as antinociceptive, which means it can block the detection of painful or damaging stimuli by sensory neurons. This pain-killing effect lasts longer and is more effective than normal analgesics. Some CBD oil users even attest that the perfect dose of CBD can match the pain relief brought by morphine and oxycodone.

CBD’s anti-inflammatory effect contributes to reducing chronic pain since inflammation only makes it worse. CBD’s ability to increase the production and release of the happy hormone, called serotonin, also plays a significant role in managing pain.

CBD for Metabolism

The endocannabinoid system plays a central role in the neuronal control of food intake and energy balance. Since the ECS comprises metabolic enzymes, it plays a crucial role in several metabolic functions like energy storage, nutrient transport, and insulin sensitivity. CBD can therefore aid in metabolism both directly and indirectly.

Aside from boosting metabolism by supporting digestion and gut health, CBD stimulates the genes and proteins that hasten the breakdown of fat. CBD can turn white fat into brown fat, decreasing the risk of diseases and potentially promoting weight loss. CBD reduces the expressions of proteins needed to create new fat cells within the body. It also helps burn calories quickly by increasing the activity of mitochondria, the powerhouse of our cells.

However, it is important to note that overstimulation of the endocannabinoid system may result in opposite effects. Too much cannabinoid intake can boost the odds of developing metabolic syndromes such as obesity and diabetes. CBD oils with small amounts of THC may also yield a different metabolic effect as THC stimulates appetite and decreases satiation.

CBD for Brain Health

Because of the mind-gut connection, many gallbladder and gastrointestinal patients are suffering from brain fog, depression, and anxiety. Inflammation in the gut translates to inflammation in the brain. And brain inflammation is more likely to develop into neurodegenerative disease.

The good thing is that CBD supports brain health too!

CBD acts upon the dopamine, serotonin, and opioid systems in the brain. The dopamine system is associated with cognition and motivation, while the serotonin system is related to mood and behavior. These hormonal functions are why CBD administration can reduce anxiety, depression, and stress. Its ability to activate serotonin receptors makes it a potential therapeutic agent for individuals suffering from addiction, PTSD, neuropathic pain, and negative symptoms of schizophrenia. CBD’s effect on dopamine levels also helps improve memory and focus.

For neuroprotection, CBD helps support cellular repair and detoxification. This can reduce the risk of developing age-related neurodegenerative diseases. CBD also facilitates a deep and restful sleep for those with insomnia and thus suffering from brain fog and lethargy.

CBD for the Immune System

CBD has a two-phased response in the immune system. Low doses have a stimulatory effect, and high dosages can trigger inhibitory activity. Either way, it can be beneficial to different sets of people.

A few studies show CBD’s effect against cancer and HIV. However, there is still much to learn about the ability of CBD to boost the immune system. At the moment, there is more proof of CBD’s anti-inflammatory effects, which in turn lowers the body’s overactive immune system. This is only good in cases where the body’s immune system has gone awry, such as in autoimmune diseases.

As a potent immune suppressor, CBD is beneficial for patients with lupus, arthritis, Parkinson’s, and multiple sclerosis, among others.

CBD Dosage and Side Effects

Numerous studies validate that cannabidiol is well tolerated and safe in humans, even at high dosages and with long-term use. Its safety and compatibility with the human body have a lot to be a naturally-occurring compound within the endocannabinoid system.

It isn’t easy to quantify what amount is enough or too little regarding dosage. There is a massive discrepancy in the amounts used in studies, from as low as 10 mg to 1300 mg. There are also different qualities and concentration levels among CBD oils which makes it difficult to set a standard. It also doesn’t help that the FDA still hasn’t recognized CBD as a supplement or prescription medicine.

Best CBD Oil

Because of the lack of regulation and standardization, there are a lot of low-quality CBD oils available in the market today. Even if it is not openly sold in many states, it is still easy to order CBD online. It is available in many forms like soft gel tablets, oil droplets, infused gum, and many more. Therefore, it is important to know what type and what brand of CBD oils you can trust.

We recommend a company called Elixinol which has a good reputation. You can tell by the prices just how concentrated they are. They are only sold on their website. Note that there is no THC in any of their products except for 0.3% in their X-pen. They have a live chat so contact them with any questions or concerns.

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