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Can CBD help with everyday ankylosing spondylitis?
Inflammation of the spine, chronic pain, arthritis, enthesitis, etc. are among the symptoms that affect anyone who suffers from ankylosing spondylitis. If there are treatments to relieve this disease, we will see through this article a treatment that will allow you to support this disease. It is the use of CBD. How can CBD help you relieve your pain? Element of answer!”
Can CBD help support ankylosing spondylitis?
To relieve the pain caused by ankylosing spondylitis, treatments such as physical therapy, exercise, massage or stretching have proven effective. However, for additional relief from pain, some patients turn to medications such as traditional painkillers, corticosteroid injections or non-steroidal anti-inflammatory drugs. But the real problem with these products is that they can cause harmful side effects. Because of this, patients are wondering if CBD can help relieve this pain.
Be aware that no exact research has been conducted on CBD to see its effectiveness in relieving ankylosing spondylitis. Nevertheless, there is a study underway to see if CBD is effective on ankylosing spondylitis and rheumatoid arthritis. According to the researchers’ explanations, the primary function of cannabinoids is to reduce inflammation. They work by interfering with the body’s endocannabinoid system. This system allows the regulation of many physiological processes in the body and the inflammatory response is no exception. Inflammation is a process that the immune system uses to respond to injury and infection. And in some critical situations, this inflammation proves to be very beneficial.
But beware, the immune system for no reason can be very active and generate inflammation. This creates a variety of pain including ankylosing spondylitis. And it is at this precise moment that CBD can be of great help. The latter helps to mitigate the functioning of the immune system to reduce pain and inflammation.
Compared to THC, which connects directly with receptors, CBD enhances the functioning of the body’s natural cannabinoid components to bring about recovery without unwanted consequences. CBD also affects receptors in addition to ECS which increases its overall effectiveness.
While CBD does not cure ankylosing spondylitis, it would provide relief from pain.
What does the research on CBD oil say about inflammation and pain?
It is true that CBD does not cure ankylosing spondylitis, but some research has been conducted on the effect of CBD oil on inflammation and pain.
According to a study published by the European Journal of Pain in 2016, researchers studied the effects of CBD on rats affected by arthritis. At the end of this experiment, it was noted that massaging the CBD gel resulted in less swelling and pain in the rats. This same study showed that CBD was able to reduce the functioning of inflammatory chemicals.
Also, another study conducted in 2019 on 97 participants with a painful condition who had been using opioids for several months, responded positively after using CBD oil.53% of participants left or decreased opioid use and 94% saw an improvement in their quality of life and enjoy better sleep.
How to use CBD for ankylosing spondylitis
There are several CBD derivatives and choosing the best one to have a positive effect against ankylosing spondylitis can be complicated. So, the first thing is whether to prioritize oral consumption, use as a topical cream or inhalation. But be aware that each of these options has its advantages and disadvantages.
CBD derivatives that you can take orally include oils, capsules, and edibles. Oral consumption allows the CBD to transit to the bloodstream through the digestive system. Thus, CBD can affect the entire body which allows for an immediate effect on systematic symptoms. Hence, the main benefit.
The disadvantage is the digestive system and the liver metabolizes much of the CBD and leaves only a tiny portion. Also, according to a WHO report, the body only uses 6% of CBD taken orally. This is wasteful considering the very high cost of very good quality CBD.
The consumer who inhales CBD has a very high bioavailability content. This is a method that takes into account vaping or smoking CBD flower. It gives an almost immediate result. But the disadvantage of inhalation is that it leads to smoking which affects the lungs. This is why experts advocate vaping since it does not emit combustion.
The use of topical creams or balms provides relief to sore areas. CBD is absorbed into the skin which provides immediate relief to inflamed or painful areas. Creams and balms may also contain other anti-inflammatory products to increase the level of relief.
The downside is that topical creams and balms are only effective on certain areas. Therefore, they cannot provide relief for people with ankylosing spondylitis.
Complete spectrum or CBD isolate: which oil to choose?
Between full spectrum or isolate, which one should you use for relief from ankylosing spondylitis? The full spectrum contains cannabinoids and terpenes on the other hand the isolate contains only CBD in its pure state or almost.
According to some experts, full spectrum CBD offers a superior result compared to isolate. Cannabinoids such as CBG and CBC are anti-inflammatory and analgesic which allows consumers to take advantage of the therapeutic properties.
In summary, while there is no concrete research on the effect of CBD on ankylosing spondylitis, there is still evidence that attests to the positive effects of CBD against inflammation and pain. This represents a real natural solution to painkillers. But beware, if it is true that CBD is without side effects or harmful, we recommend that anyone who tries it for the first time to take the advice of a doctor. The latter will ensure that CBD is the right treatment in order to solve their inflammatory problems.
Les articles et autres fiches produits en ligne sur notre site web ne représentent en aucun cas des conseils médicaux. Avant toute consommation d’un produit CBD nous vous conseillons de prendre contact avec votre médecin et de lui demander son avis.
Can Cannabis Help Ankylosing Spondylitis?
Cannabis treatment has been shown to have anti-inflammatory benefits and help treat common symptoms of ankylosing spondylitis (AS) such as pain . Currently, no studies have been published on cannabis as a treatment option specifically for AS. That being said, a randomized controlled trial is underway which is exploring the effects of the prime molecules in cannabis, such as CBD and THC , on AS symptoms.
Cannabis has been shown to help reduce pain associated with conditions that share symptoms with AS such as fibromyalgia , chronic back/neck pain , osteoarthritis , rheumatoid arthritis , migraines , and menstrual pain .
Reviews of studies have also confirmed that there is an overall positive association between cannabis use and pain relief. That being said, these studies examined the pain relief properties of cannabis in specific conditions, and not specifically for AS-related pain.
Additionally, there are many types of cannabis strains. Research is yet to confirm whether specific strains are more or less effective for treating specific diseases.
How Cannabis Works on Ankylosing Spondylitis
The endocannabinoid system (ECS) exists in all vertebrates and helps regulate crucial functions such as sleep, pain, and appetite. The human body produces its own cannabinoids, which modulate and activate its various functions, but as its name suggests, the endocannabinoid system can also be modulated and activated by cannabinoids found in the cannabis plant. Because the entire system was only discovered in the past 30 years, scientists still have much to learn about the myriad ways cannabis affects the human body.
The endocannabinoid system and its CB1 and CB2 receptors regulate pain and inflammatory processes. Cannabinoid receptors are dispersed around different areas of the body. Both CB1 and CB2 receptors can be influenced by cannabis.
CB1 receptors are abundant in the brain and central nervous system. They are found in regions of the peripheral and central nervous system where pain signaling occurs, and therefore modulates pain. Activating CB1 receptors may, therefore, help with pain relief.
CB2 receptors , on the other hand, are primarily expressed on immune cells. They are also found in the brain but in far lower concentrations and have also been found on bone and connective tissue cells . The activation of CB2 receptors has been shown to decrease several markers of inflammation.
Ankylosing spondylitis causes pain and inflammation, which are two functions the endocannabinoid system plays a role in regulating. The stimulation of the endocannabinoid system may, therefore, help with reducing symptoms such as pain and inflammation caused by AS.
Research on Ankylosing Spondylitis and Cannabis
Current research has established the positive benefits cannabis has for pain in conditions such as rheumatoid arthritis and fibromyalgia, which share some similarities to ankylosing spondylitis.
Cannabis has been approved for Crohn’s disease and ulcerative colitis, which are conditions that fall under a group of diseases known as PAIR that AS is also categorized under ( psoriatic arthritis , ankylosing spondylitis, IBD ( crohn’s disease and ulcerative colitis ), and reactive arthritis).
The following studies — although not on AS specifically — shed light on the potential of cannabis to reduce symptoms of AS as it does in related conditions.
- This systematic review looked at the results of 28 studies on cannabis and chronic pain. The researchers concluded that “there was moderate-quality evidence to support the use of cannabinoids for the treatment of chronic pain.” Overall, these results show that cannabis use tends to be associated with reductions in pain. That being said, the sample sizes of the selected studies were small.
- One study investigated the direct effects of cannabis on Crohn’s disease. Twenty-one out of 30 patients experienced significant improvements in their disease activity, use of medication, and need for surgery before and after cannabis use.
- In a 2018 report , the results of a randomized double-blind placebo controlled study showed that cannabidiol-rich treatment of patients with ulcerative colitis helped 59% of them experience remission rates of 28%. The study participants received a CBD-rich extract that contained 4% THC.
- One randomized controlled trial published in 2008 found that Nabilone (which mimics THC) improved pain from fibromyalgia compared to placebo over four weeks.
- In a 2006 randomized controlled trial , Sativex (1:1 THC:CBD) was shown to decrease pain in participants with rheumatoid arthritis. Out of 58 patients, 31 were given Sativex and 27 were given a placebo. Researchers found that patients using Sativex experienced decreases in pain on movement and improved sleep.
- In a randomized controlled trial , researchers administered inhaled cannabis containing 9.4% THC to patients with neuropathic pain. The treatment resulted in significant reductions in pain compared to the placebo group.
Cannabis appears to be effective for relieving neuropathic pain, reducing inflammation, and decreasing pain from rheumatoid arthritis, fibromyalgia, and improving other conditions related to AS such as Crohn’s disease and ulcerative colitis.
While cannabis is beneficial for other conditions, more clinical research that examines the effectiveness of cannabis in AS should be done.
CBD and Ankylosing Spondylitis
Human and animal studies show CBD is effective for reducing pain in several conditions. Animal studies — but not human studies — show CBD helps reduce arthritic pain. AS is a form of arthritis, and therefore CBD may help with symptoms in humans.
- The results from a 2018 review showed that CBD was effective for relieving neuropathic pain, cancer pain, and fibromyalgia pain.
- In one 2017 study , researchers looked at how CBD affects joint degeneration and inflammation. Researchers induced osteoarthritis in rats, and then administered a CBD treatment and examined the effects. CBD was found to prevent further pain development and nerve damage in joints.
- One 2014 review on the existing animal research concluded that CBD may be effective for treating osteoarthritis.
- A 2011 study looked at how CBD affects the response of pain receptors in rat models. Researchers found that CBD was able to decrease inflammatory pain.
The promising research on CBD and pain has given scientists enough confidence to pursue a clinical trial to confirm the effects CBD has on AS patients.
In a double-blind randomized placebo-controlled study , researchers from Denmark will be testing whether CBD helps chronic pain in patients with rheumatoid arthritis or AS. An oral CBD treatment in the experiment group will be compared to a placebo over 12 weeks. There will be a 12-week observational period that will follow with the add-on of THC for CBD ‘non-responders’. Physiological and psychological markers will be collected after 12 and 24 weeks of treatment with a final follow up at 36 weeks.
The aim of the study is to test whether CBD and THC help with pain and also to assess the effect of cannabis treatments on cognitive function and sleep. Testing other factors besides pain will help researchers understand the viability of cannabis as a treatment for both conditions.
CBD is effective for pain, but we need to wait for the results of this CBD-AS trial to be published for a definite answer.
Potential side effects of cannabis use
Cannabis is well-tolerated and safe to use as a treatment for pain.
Cannabis has been shown to cause short-term side effects such as impaired concentration, fatigue, changes to mood, appetite, and perception.
The long-term side effects of cannabis are largely contingent on the extent of one’s use, the age at which one starts using cannabis, and genetic predispositions to developing mental health conditions such as schizophrenia, substance abuse disorder, and bipolar disorder).
When considering the use of cannabis for symptoms of AS, it’s critical to consult with your doctor before starting treatment.